Hyperbaric oxygen therapy and corticosteroids as combined treatment for acute acoustic trauma.

Purpose: Acute acoustic trauma (AAT) is a sudden sensorineural hearing loss (SNHL) due to exposure to high intensity impulse noise. There are no acceptable treatment guidelines, although several studies showed steroids could be effective in restoring hearing levels. A recent report suggested that steroids combined with hyperbaric oxygen therapy (HBOT) are a superior regiment for AAT.

Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model.

Introduction: Diving utilising closed circuit pure oxygen rebreather systems has become popular in professional settings. One of the hazards the oxygen diver faces is central nervous system oxygen toxicity (CNS-OT), causing potentially fatal convulsions. At the same time, divers frequently travel by boat, often suffering seasickness.

From acceptance to change: The role of acceptance in the effectiveness of the Informative Process Model for conflict resolution.

The Informative Process Model (IPM) proposes an intervention to facilitate change in conflict-supporting narratives in protracted conflicts. These narratives develop to help societies cope with conflict; but over time, they turn into barriers for its resolution. The IPM suggests raising awareness of the psychological processes responsible for the development of these narratives and their possibility for change, which may unfreeze conflict attitudes.

A digoxin derivative that potently reduces intraocular pressure: efficacy and mechanism of action in different animal models.

Glaucoma is a blinding disease. Reduction of intraocular pressure (IOP) is the mainstay of treatment, but current drugs show side effects or become progressively ineffective, highlighting the need for novel compounds. We have synthesized a family of perhydro-1,4-oxazepine derivatives of digoxin, the selective inhibitor of Na,K-ATPase.