Publications by authors named "D M Suyoga Vardhan"
Electroencephalography (EEG) waves and other biological signals can be deciphered with a deeper understanding of the human body. The benefits of EEG are growing. EEG studies have expanded globally.
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- Many patients referred for complex molecular profiling of tumors may have inherited genetic variants linked to hereditary cancer syndromes (HCS), but there's no standard method for analyzing or reporting these findings.
- Data from Next-Generation Sequencing (NGS) was used to identify germline variants in genes tied to HCS, with validation through bioinformatic algorithms and Sanger sequencing when possible.
- Out of 183 sampled patients, 56 variants were found in 40 individuals, with 17 of those likely originating from germline mutations, including 6 classified as pathogenic and 9 as variants of uncertain significance; the study suggests a minimal need for further tissue sequencing in a few cases to confirm these findings.
In the quest for new active molecules against Mycobacterium tuberculosis, a series of dihydroquinoline derivatives possessing triazolo substituents were efficiently synthesized using click chemistry. The structure of 6l was evidenced by X-ray crystallographic study. The newly synthesized compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv (ATCC27294).
View Article and Find Full Text PDFSynthesis of a series of urea and thiourea derivatives of glycine and proline conjugated to 2,3-dichlorophenyl piperazine has been reported. The structures were confirmed by physical and spectroscopical measurements followed by characterization of antiglycation activity. All synthesized compounds were able to inhibit protein glycation, particularly halogen containing derivatives without preference of oxygen or sulphur at the urea function.
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