Publications by authors named "D M Spooner"
Oestrogen receptor (ER)-positive breast cancer (BC) is generally well responsive to endocrine therapy. Neoadjuvant endocrine therapy (NAET) is increasingly being used for downstaging ER-positive tumours. This study aims to analyse the effect of NAET on a well-characterised cohort of ER-positive BC with particular emphasis on receptor expression.
View Article and Find Full Text PDFPer- and polyfluoroalkyl substances (PFAS) have extensively contaminated freshwater aquatic ecosystems where they can be transported in water and partition to sediment and biota. In this paper, three freshwater benthic macroinvertebrates with different foraging modes were exposed to environmentally relevant concentrations of eight perfluoroalkyl carboxylates (PFCA), three perfluoroalkyl sulfonates (PFSA), and three fluorotelomer sulfonates (FTS) at varying divalent cation concentrations of magnesium (Mg) and calcium (Ca). Divalent cations can impact PFAS partitioning to solids, especially to sediments, at higher concentrations.
View Article and Find Full Text PDFPer- and polyfluoroalkyl substances (PFAS) in aquatic environments have caused global concern due to their persistence, toxicity, and potential bioaccumulation of some compounds. As an important compartment of the aquatic ecosystem, sediment properties impact PFAS partitioning between aqueous and solid phases, but little is known about the influence of sediment organic carbon content on PFAS bioaccumulation in benthic organisms. In this study, three freshwater benthic macroinvertebrates - worms (Lumbriculus variegatus), mussels (Elliptio complanata) and snails (Physella acuta) - were exposed for 28 days to PFAS spiked synthetic sediment equilibrated with a synthetic surface water.
View Article and Find Full Text PDFArticle Synopsis
- * Examination revealed serious eye conditions, including anterior uveitis and retinal detachments, confirmed through imaging.
- * The patient was treated with intravenous steroids, leading to significant improvement in her vision and eye health within a week, underscoring the need for prompt ophthalmologic evaluation in cancer treatment.
Article Synopsis
- * Analysis of 93 untreated IBC samples showed that lower-grade tumors had fewer CD4+ cells but more FOXP3+ cells; higher CD20+ cell levels were linked to better chemotherapy responses.
- * The study found distinct immune cell patterns in various subtypes of IBC, suggesting that understanding these patterns could improve therapies and contribute to developing immunotherapy strategies.