Antisense Oligonucleotide STK-002 Increases OPA1 in Retina and Improves Mitochondrial Function in Autosomal Dominant Optic Atrophy Cells.

Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy most frequently associated with mutations. Most variants result in haploinsufficiency, and patient cells express roughly half of the normal levels of OPA1 protein. OPA1 is a mitochondrial GTPase that is essential for normal mitochondrial function.

A review of machine learning in scanpath analysis for passive gaze-based interaction.

The scanpath is an important concept in eye tracking. It refers to a person's eye movements over a period of time, commonly represented as a series of alternating fixations and saccades. Machine learning has been increasingly used for the automatic interpretation of scanpaths over the past few years, particularly in research on passive gaze-based interaction, i.

Sensitivity of air quality to vehicle ammonia emissions in the United States.

The US Environmental Protection Agency (EPA) estimates on-road vehicles emissions using the Motor Vehicle Emission Simulator (MOVES). We developed updated ammonia emission rates for MOVES based on road-side exhaust emission measurements of light-duty gasoline and heavy-duty diesel vehicles. The resulting nationwide on-road vehicle ammonia emissions are 1.

Reactive organic carbon air emissions from mobile sources in the United States.

Mobile sources are responsible for a substantial controllable portion of the reactive organic carbon (ROC) emitted to the atmosphere, especially in urban environments of the United States. We update existing methods for calculating mobile source organic particle and vapor emissions in the United States with over a decade of laboratory data that parameterize the volatility and organic aerosol (OA) potential of emissions from on-road vehicles, nonroad engines, aircraft, marine vessels, and locomotives. We find that existing emission factor information from Teflon filters combined with quartz filters collapses into simple relationships and can be used to reconstruct the complete volatility distribution of ROC emissions.

Cross-Viewpoint Semantic Mapping: Integrating Human and Robot Perspectives for Improved 3D Semantic Reconstruction.

Allocentric semantic 3D maps are highly useful for a variety of human-machine interaction related tasks since egocentric viewpoints can be derived by the machine for the human partner. Class labels and map interpretations, however, may differ or could be missing for the participants due to the different perspectives. Particularly, when considering the viewpoint of a small robot, which significantly differs from the viewpoint of a human.