Publications by authors named "D M Schulte"
Glioblastoma, the most frequent primary malignant brain tumour in adults, is characterised by profound yet dynamic hypoxia and nutrient depletion. To sustain survival and proliferation, tumour cells are compelled to acquire metabolic plasticity with the induction of adaptive metabolic programs. Here, we interrogated the pathways necessary to enable processing of nutrients other than glucose.
View Article and Find Full Text PDFMass spectral libraries are collections of reference spectra, usually associated with specific analytes from which the spectra were generated, that are used for further downstream analysis of new spectra. There are many different formats used for encoding spectral libraries, but none have undergone a standardization process to ensure broad applicability to many applications. As part of the Human Proteome Organization Proteomics Standards Initiative (PSI), we have developed a standardized format for encoding spectral libraries, called mzSpecLib (https://psidev.
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- Periodontitis is linked to systemic chronic inflammatory diseases, but there's limited understanding of how anti-cytokine therapies affect periodontal health and microbiome in such patients.
- This study involved 13 patients, assessing their periodontal status and gingival fluid before and 14 weeks after starting anti-cytokine treatment, with a focus on changes in the microbiome.
- Results showed a significant increase in microbial diversity, suggesting improvement in periodontal health, indicating a need for further research on the effects of biological treatments on periodontal conditions.
Less than 7000 cheetahs (Acinonyx jubatus) persist in Africa. Although human-wildlife conflict, habitat degradation, and loss of prey are major threats to cheetah populations, illegal trade in live cubs for pets may have the most significant impact on populations in the Horn of Africa. We developed a novel, stepwise decision support tool to predict probable trafficking routes by leveraging the power of distinct modeling approaches.
View Article and Find Full Text PDFBackground: Biomedical and lifestyle factors in Western populations have significantly shifted in recent decades, influencing public health and contributing to the increasing prevalence of non-communicable diseases (NCDs) that share inflammation as common pathology.
Methods: We investigated the relationship between these factors and 11 NCDs in the cross-sectional FoCus cohort (n = 1220), using logistic regression models. Associations with age-at-disease-onset were specifically analyzed for type 2 diabetes (T2D, low-grade chronic inflammation) and inflammatory bowel disease (IBD, high-grade chronic inflammation) in disease-specific cohorts (FoCus-T2D, n = 514; IBD-KC, n = 1110).