High-resolution monthly precipitation and temperature time series from 2006 to 2100.

Predicting future climatic conditions at high spatial resolution is essential for many applications and impact studies in science. Here, we present monthly time series data on precipitation, minimum- and maximum temperature for four downscaled global circulation models. We used model output statistics in combination with mechanistic downscaling (the CHELSA algorithm) to calculate mean monthly maximum and minimum temperatures, as well as monthly precipitation at ~5 km spatial resolution globally for the years 2006-2100.

Risk of genetic maladaptation due to climate change in three major European tree species.

Tree populations usually show adaptations to their local environments as a result of natural selection. As climates change, populations can become locally maladapted and decline in fitness. Evaluating the expected degree of genetic maladaptation due to climate change will allow forest managers to assess forest vulnerability, and develop strategies to preserve forest health and productivity.

Scaffolds Containing Spirulina sp. LEB 18 Biomass: Development, Characterization and Evaluation of In Vitro Biodegradation.

Polymer nanofibers are nanomaterials that can be used as scaffolds in tissue engineering. The objective of this study was to develop, characterize and evaluate the in vitro degradation of a biomaterial consisting of nanofibers produced from biodegradable and biocompatible polymers with potential applications as a scaffold for tissue regeneration and containing Spirulina sp. LEB 18 biomass as the bioactive compound.

Hit and lead criteria in drug discovery for infectious diseases of the developing world.

Reducing the burden of infectious diseases that affect people in the developing world requires sustained collaborative drug discovery efforts. The quality of the chemical starting points for such projects is a key factor in improving the likelihood of clinical success, and so it is important to set clear go/no-go criteria for the progression of hit and lead compounds. With this in mind, the Japanese Global Health Innovative Technology (GHIT) Fund convened with experts from the Medicines for Malaria Venture, the Drugs for Neglected Diseases initiative and the TB Alliance, together with representatives from the Bill &Melinda Gates Foundation, to set disease-specific criteria for hits and leads for malaria, tuberculosis, visceral leishmaniasis and Chagas disease.