Publications by authors named "D M Randall"
This is an unusual case of voltage gated calcium channel (VGCC) antibodies leading to two distinct and chronologically separated neurologic syndromes without the presence of an underlying neoplasm. Lambert Eaton Myasthenic Syndrome (LEMS) presented five years prior to cerebellar ataxia. Both LEMS and cerebellar ataxia were responsive to treatment, but not the same therapy.
View Article and Find Full Text PDFIntroduction: The incidence of gestational diabetes mellitus (GDM) in Australia has tripled in the last 20 years. Consequently, over 40 000 pregnancies are now diagnosed as 'higher risk' each year. This has increased antenatal surveillance and obstetric intervention, often in the form of delivery earlier than 39 weeks gestation.
View Article and Find Full Text PDFThe gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence indicates the involvement of gut microbe-derived metabolites. Circulating levels of the gut microbe/host co-metabolite -cresol sulfate (pCS) correlate with cerebrovascular event risk in individuals with chronic kidney disease (CKD), but whether this relationship is mechanistic is unclear.
View Article and Find Full Text PDFOral dysbiosis initiates periodontal disease in experimental kidney disease.
Nephrol Dial Transplant
November 2024
Article Synopsis
- - The study explores the link between chronic kidney disease (CKD) and periodontal disease, proposing that changes in saliva and oral microbiota due to CKD could initiate periodontal disease rather than the other way around.
- - Using animal models, researchers found that kidney disease led to a significant reduction in alveolar bone height and caused changes in salivary biochemistry and oral microbiota composition, resulting in a dysbiotic environment.
- - Findings suggest that interactions between oral bacteria and the systemic conditions of CKD can exacerbate periodontal issues, as co-housing healthy rats with those having kidney disease improved periodontal health, while transferring diseased microbiota caused periodontal disease in healthy mice.
Introduction: Intralesional corticosteroid injection for management of subglottic stenosis (SGS) is thought to improve patients' surgery free interval (SFI). The objective of this study was to determine the difference in SFI between idiopathic SGS (iSGS) patients treated with endoscopic dilation alone, dilation with a single intraoperative intralesional corticosteroid injection, or dilation with intraoperative steroid injection followed by serial in-office serial intralesional steroid injection (SILSI) procedures.
Methods: Retrospective review of patients with iSGS from 1/1/2012 to 12/1/2023.