Publications by authors named "D M Pezet"
Adipose tissue (AT), is a major endocrine organ that plays a key role in health and disease. However, adipose dysfunctions, especially altered energy metabolism, have been under-investigated as white adipocytes have relatively low mitochondrial density. Nevertheless, recent studies suggest that mitochondria could play a major role in AT disorders and that AT mitochondrial activity could depend on adiposity level and location.
View Article and Find Full Text PDFIntroduction: The impact of overweight and obesity on pathological outcomes, complications, and oncologic outcomes following surgery for gastric adenocarcinoma has been poorly reported in Western populations. This study aimed to better understand the impact of overweight and obesity on both surgical and oncological outcomes in patients who underwent surgery for gastric cancer.
Methods: Data were retrospectively collected from a multi-institutional European database.
Article Synopsis
- Cachexia, a condition often linked to digestive cancers like oesophagogastric cancer, is believed to be influenced by mitochondrial activity in adipose tissue, particularly in response to chemotherapy.
- The ChiFMeOE study aims to investigate how cachexia affects energy metabolism in fat cells and how these changes respond to chemotherapy in patients undergoing treatment for specific types of cancer.
- This study will include 60 patients and focus on collecting tissue biopsies and assessing mitochondrial function, while ensuring ethical standards are maintained through proper consent and oversight.
Background: Despite the increasing efficacy of chemotherapy, permanently unresectable colorectal liver metastases are associated with poor long-term survival. We aimed to assess whether liver transplantation plus chemotherapy could improve overall survival.
Methods: TransMet was a multicentre, open-label, prospective, randomised controlled trial done in 20 tertiary centres in Europe.
Background: The prevalence of microsporidiosis in the general population, or within specific groups of individuals/patients, is largely underestimated. The absence of specific seroprevalence tools limits knowledge of the epidemiology of these opportunistic pathogens, although known since the 1980s. Since microsporidia hijack the machinery of its host cell and certain species multiply within intestinal cells, a potential link between the parasite and colorectal cancer (CRC) has been suggested.
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