Publications by authors named "D M Pardoll"
Article Synopsis
- The adaptive T cell response involves changes in their electric and metabolic states due to ion channels and nutrient transporters responding to environmental signals.
- In a study with mice, neuritin was found to play a significant role in developing tolerance by affecting both regulatory and effector T cell functions.
- A lack of neuritin led to improper regulation of ion channels and nutrient transporters in T cells, which disrupted their metabolic processes and was linked to the progression of autoimmune diseases.
Article Synopsis
- Co-mutations of KRAS and STK11 genes in advanced non-small cell lung cancer (NSCLC) are linked to resistance against immune checkpoint blockade (ICB) therapies, although their impact in patients receiving neoadjuvant chemoimmunotherapy remains unclear.
- A study investigated how these gene mutations affect recurrence-free survival in resectable KRAS-mutated NSCLC, revealing that those with co-occurring STK11 mutations had a higher risk of recurrence compared to those without.
- Analysis of tumor-infiltrating T cells indicated that the presence of STK11 mutations altered T cell behavior, suggesting that certain T cell characteristics might hinder effective anti-tumor immune responses in patients with KRASmut/STK11
: Preclinical and clinical data indicate that chemoradiotherapy (CRT) in combination with checkpoint inhibitors may prime an anti-tumor immunological response in esophageal cancer. However, responses to neoadjuvant therapy can vary widely and the key biomarkers to determine response remain poorly understood. The fecal microbiome is a novel and potentially modifiable biomarker of immunotherapy response, and both fecal and tumor microbes have been found to associate with outcomes in esophageal cancer.
View Article and Find Full Text PDFIntroduction: This is a prospective, rigorous inquiry into the systemic immune effects of standard adjuvant chemoradiotherapy, for WHO grade 4, glioblastoma. The purpose is to identify peripheral immunologic effects never yet reported in key immune populations, including myeloid-derived suppressor cells, which are critical to the immune suppressive environment of glioblastoma. We hypothesize that harmful immune-supportive white blood cells, myeloid derived suppressor cells, expand in response to conventionally fractionated radiotherapy with concurrent temozolomide, essentially promoting systemic immunity similar what is seen in chronic diseases like diabetes and heart disease.
View Article and Find Full Text PDFArticle Synopsis
- Malignant peripheral nerve sheath tumors (MPNST) pose a significant risk to patients with neurofibromatosis type 1 (NF1), with current treatments failing to improve outcomes, highlighting the need for new therapies that target the tumor's immune environment.
- Researchers examined the immune microenvironment in NF1-associated tumors, using various techniques to analyze how immune cells infiltrate and respond to these tumors.
- Results showed that malignant progression involved increased infiltration of specific immune cells, particularly tumor-associated macrophages, linked to worse patient outcomes, indicating a potential for therapies that can enhance anti-tumor immune responses.