Publications by authors named "D M Odorico"
Article Synopsis
- The deployment of a public health rapid response team (PHRRT) in Central Queensland during COVID-19 outbreaks in residential aged care facilities (RACFs) led to improved management and outcomes.
- The existing vaccine surveillance framework helped promptly identify symptomatic residents, triggering timely interventions from the PHRRT.
- Following the PHRRT's involvement, there were significantly fewer hospital admissions and deaths, highlighting the importance of effective communication and resource optimization in protecting vulnerable elderly populations.
Article Synopsis
- An updated checklist of Mozambique's vascular plants lists 7,099 taxa (including species, subspecies, and varieties) from 226 families and 1,746 genera, based on various sources like literature and online databases.
- The checklist highlights that 6,171 taxa are native to Mozambique, with a notable flora endemism level of 9.59%, including both strict and near-endemic species.
- It also assesses extinction risk for 1,667 taxa, identifying 158 as Vulnerable and 119 as Endangered, while providing information on geographical distribution, vernacular names, and traditional plant uses.*
Kallikrein 4 (KLK4) is a member of the human KLK gene family of serine proteases, many of which are implicated in hormone-dependent cancers. Like other KLKs, such as KLK3/PSA and KLK2, KLK4 gene expression is also regulated by steroid hormones in hormone-dependent cancers, although the transcriptional mechanisms are ill defined. Here, we have investigated the mechanisms mediating the hormonal regulation of KLK4 in breast (T47D) and prostate (LNCaP and 22Rv1) cancer cells.
View Article and Find Full Text PDFThe prostate-specific antigen-related serine protease gene, kallikrein 4 (KLK4), is expressed in the prostate and, more importantly, overexpressed in prostate cancer. Several KLK4 mRNA splice variants have been reported, but it is still not clear which of these is most relevant to prostate cancer. Here we report that, in addition to the full-length KLK4 (KLK4-254) transcript, the exon 1 deleted KLK4 transcripts, in particular, the 5'-truncated KLK4-205 transcript, is expressed in prostate cancer.
View Article and Find Full Text PDFPurpose: The disintegrin metalloprotease ADAM-10 is a multidomain metalloprotease that is potentially significant in tumor progression due to its extracellular matrix-degrading properties. Previously, ADAM-10 mRNA was detected in prostate cancer (PCa) cell lines; however, the presence of ADAM-10 protein and its cellular localization, regulation, and role have yet to be described. We hypothesized that ADAM-10 mRNA and protein may be regulated by growth factors such as 5alpha-dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor, known modulators of PCa cell growth and invasion.
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