Publications by authors named "D M Muinck Keizer"
Introduction: Immune checkpoint inhibition (ICI) is highly effective for the treatment of melanoma, but intrinsic resistance is present in a subgroup of patients. TGF-β pathway activity may play a role in this resistance by preventing T-cells from entering the tumor microenvironment, causing immune escape. We investigated the association of TGF-β signal transduction pathway activity with resistance to ICI treatment in advanced melanoma.
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- The transition of older hospital patients to appropriate post-acute care has become critical due to demographic changes and limited hospital stays.
- A national web-based survey gathered input from hospital and geriatric rehabilitation professionals in the Netherlands regarding current assessment practices for guiding post-acute care decisions.
- Results indicated mixed satisfaction with the triage process, highlighting differing perspectives between sending and receiving professionals, particularly on patient involvement and the importance of triage items.
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- In lipidic cubic phases (LCPs), H NMR spectra are mainly affected by water and lipid molecules, making it hard to measure the diffusion of peptides/molecules.
- Conventional H pulsed-gradient spin-echo (PGSE) NMR struggles due to the overwhelming signals from the environment.
- The study introduces a band-selective short transient PGSE sequence that reduces interference from water and lipids, allowing for accurate diffusion measurements of encapsulated molecules.
Background: Response to hormonal therapy in advanced and recurrent endometrial cancer (EC) can be predicted by oestrogen and progesterone receptor immunohistochemical (ER/PR-IHC) expression, with response rates of 60% in PR-IHC > 50% cases. ER/PR-IHC can vary by tumour location and is frequently lost with tumour progression. Therefore, we explored the relationship between ER/PR-IHC expression and tumour location in EC.
View Article and Find Full Text PDFTwo-dimensional NOE (nuclear Overhauser effect) NMR spectroscopy was employed to investigate the dynamic properties of water within lyotropic bicontinuous lipidic cubic phases (LCPs) formed by monoolein (MO). Experiments observed categorically different effective residence times of water molecules: (i) in proximity to the glycerol moiety of MO, and (ii) adjacent to the hydrophobic chain towards the hydrocarbon tail of MO, as evidenced by the opposite signs of intermolecular NOE cross peaks between protons of water and those of MO in 2D H-H NOESY spectra. Spectroscopic data delineating the different effective residence times of water molecules within both the gyroid (Q) and diamond (Q) phase groups corresponding to hydration levels of 35 and 40 wt%, respectively, are presented.
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