Publications by authors named "D M Morgenstern"
Proteasomes are essential for protein degradation and maintaining cellular balance, yet their roles in extracellular fluids are not well understood. Our study investigates the freely circulating proteasome in blood, to uncover its unique molecular characteristics, compared to its intracellular counterparts. Using a transgenic mouse model, mass spectrometry, and biochemical tools, we show that the predominant proteasome in serum is the free uncapped 20S particle, which seems to assemble intracellularly before entering the bloodstream.
View Article and Find Full Text PDFLarotrectinib is a highly selective tropomyosin receptor kinase (TRK) inhibitor with efficacy in children with TRK fusion tumors. We evaluated patient outcomes after elective discontinuation of larotrectinib in the absence of disease progression in a protocol-defined wait-and-see subset analysis of eligible patients where treatment resumption with larotrectinib was allowed if disease progressed. We also assessed the safety and efficacy of larotrectinib in all pediatric patients with sarcoma.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed how well diffusion-weighted MRI can distinguish between malignant neuroblastoma and benign neuroblastic tumors, using different sizes of regions of interest (ROIs).
- The research involved 40 pediatric patients and compared the imaging results with histopathology to establish diagnostic accuracy, showing strong sensitivity (83%) and specificity (75%) for using the apparent diffusion coefficient (ADC).
- The findings suggest that small ROIs may yield slightly better accuracy in differentiating these tumor types, emphasizing the importance of standardizing ROI sizes in future studies.
Investigating the Potential of Haptic Props for 3D Object Manipulation in Handheld AR.
IEEE Trans Vis Comput Graph
November 2024
The manipulation of virtual 3D objects is essential for a variety of handheld AR scenarios. However, the mapping of commonly supported 2D touch gestures to manipulations in 3D space is not trivial. As an alternative, our work explores the use of haptic props that facilitate direct manipulation of virtual 3D objects with 6 degrees of freedom.
View Article and Find Full Text PDFImportance: The combination of ifosfamide and etoposide (IE) is commonly used to treat relapsed or refractory osteosarcoma; however, second-line treatment recommendations vary across guidelines.
Objective: To evaluate whether the addition of lenvatinib to IE (LEN-IE) improves outcomes in children and young adults with relapsed or refractory osteosarcoma.
Design, Setting, And Participants: The OLIE phase II, open-label, randomized clinical trial was conducted globally across Europe, Asia and the Pacific, and North America.