Publications by authors named "D M Miyamoto"
Circulating Tumor Cells (CTCs) in blood encompass DNA, RNA, and protein biomarkers, but clinical utility is limited by their rarity. To enable tumor epitope-agnostic interrogation of large blood volumes, we developed a high-throughput microfluidic device, depleting hematopoietic cells through high-flow channels and force-amplifying magnetic lenses. Here, we apply this technology to analyze patient-derived leukapheresis products, interrogating a mean blood volume of 5.
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- The study focused on chemically induced liver progenitors (CLiP) derived from steatotic livers in miniature pigs to assess their potential for future liver disease treatment.
- CLiP from steatotic livers showed a higher ability to proliferate compared to those from healthy livers, but only the normal group demonstrated mature liver cell functionality after re-differentiation.
- Despite the lower production of extracellular vesicles (EVs) in the disease group, the overall findings suggest that CLiP from steatotic livers could be a viable option for cell therapy in liver disease patients.
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- * A 70-year-old woman with pulmonary arterial hypertension struggled with exercise due to breathing difficulties, so she underwent three sessions of lower-leg bathing at 42°C, which improved her symptoms and allowed her to begin exercise therapy.
- * While lower-leg bathing showed temporary benefits in symptom relief, its effects did not last long-term, but it may still be a viable option for patients with severe pulmonary hypertension when traditional exercise therapies are challenging.
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- Auditory fear conditioning strategies differ based on working memory, but how they are affected by sleep and extinction in long-term processing remains unclear.
- In a study on male and female mice, sleep deprivation after conditioning didn't impact delay fear memory during extinction training but did reduce persistent fear in females during remote recall.
- The findings point to sleep deprivation enhancing extinction in both short and long-term scenarios for different conditioning methods, emphasizing the need to consider emotional memory, sleep, and gender differences in PTSD research and treatment.
Background & Aims: Polystyrene microplastics (PS-MPs) are pervasive in our daily life and can be ingested by the human body through bioaccumulation, causing organ damage, especially liver damage. However, the effect of PS-MPs bioaccumulation on human hepatotoxicity and their metabolism remains unclear. Recent studies have demonstrated that PS-MPs cause lipid and bile acid metabolism disorders.
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