Publications by authors named "D M Maiter"
Introduction: Lipodystrophy syndromes are rare diseases characterized by a generalized or partial lipoatrophic morphotype and metabolic complications. Data on health-related quality of life and impact of genetic lipodystrophy on social or psychological well-being are lacking.
Patients And Methods: Patients with genetic lipodystrophy were recruited throughout the French national reference network for rare diseases of insulin secretion and insulin sensitivity.
Article Synopsis
- Aggressive pituitary neuroendocrine tumors (PitNETs) often grow despite treatment and can metastasize, making them particularly challenging to manage.
- This study analyzed tumor samples from 64 patients to investigate genetic markers, finding distinct patterns between aggressive/metastatic tumors and benign ones through genome-wide methylation and chromosomal analyses.
- The results indicate potential biomarkers that could help in identifying high-risk patients earlier, refining treatment protocols, and improving outcomes for those with aggressive pituitary tumors.
Article Synopsis
- Pituitary adenomas (PA), or Pit-NETS, are rare in children and especially unusual in those under 10, with the majority of research conducted on adult cases.
- This review addresses the unique clinical considerations, diagnosis, and treatment of PA in young patients, highlighting the importance of involving specialized teams that include both pediatric and adult medical experts.
- Pediatric PAs tend to be larger, more aggressive, and often lead to hormonal imbalances that can affect growth and puberty, with the most common type being prolactinomas; genetic testing is recommended for young patients due to potential hereditary mutations linked to these tumors.