In vivo assessment of bladder cancer with diffuse reflectance and fluorescence spectroscopy: A comparative study.

Objectives: The aim of this work is to assess the performance of multimodal spectroscopic approach combined with single core optical fiber for detection of bladder cancer during surgery in vivo.

Methods: Multimodal approach combines diffuse reflectance spectroscopy (DRS), fluorescence spectroscopy in the visible (405 nm excitation) and near-infrared (NIR) (690 nm excitation) ranges, and high-wavenumber Raman spectroscopy. All four spectroscopic methods were combined in a single setup.

Development of a Sensitive Digital Droplet PCR Screening Assay for the Detection of Non-Coding Mutations in Bladder Cancer Urine Liquid Biopsies.

Recent whole-genome sequencing studies identified two novel recurrent mutations in the enhancer region of in urothelial bladder cancer (UBC) tumor samples. This mutational hotspot is the second most common after the promoter in UBC. The aim of the study was to develop a digital droplet PCR screening assay for the simultaneous detection of mutations in a single tube.

Urine TERT promoter mutations-based tumor DNA detection in patients with bladder cancer: A pilot study.

Telomerase reverse transcriptase (TERT) promoter mutations are the most frequent genetic events in bladder cancer (BC). The aim of the present pilot study was to evaluate the diagnostic potential of urine TERT promoter mutations-based liquid biopsy in patients with an ongoing oncological process, as well as in post-resection patients at risk of BC recurrence. A total of 60 patients were enrolled, of whom 27 patients had histologically proven BC; 23 had no signs of BC (control group); and 10 patients underwent transurethral malignancy resection 3-6 months prior to urine donation ('second look' group).

[Varicocele and reproductive function: epidemiology and infertility risk (the eamination of 3632 patients)].

Unlabelled: Varicocele does not always lead to infertility; varicocelectomy does not always improve sperm.

The Study Objective: to evaluate the quantitative correlation between varicocele and reproductive function with a large sample.

Design: a cross-sectional and case control study.

[Varicocele and reproductive function: pathozoospermia treatment (a prospective comparative study)].

Unlabelled: Varicocele does not always lead to infertility; varicocelectomy does not always improve sperm.

Objective: to evaluate the standardized effect (Es) of nutrient therapy, microsurgical and laparoscopic varicocelectomy for pathozoospermia.

Study Design: a multicenter case-control study with stratified randomization.