Publications by authors named "D M Hollins"
The mutation was generated in a Flp/FRT EMS screen for conditional mutations that cause growth and developmental defects in a genetic background that blocks apoptosis. The mutations were conditional, based on the allele being present on the starting chromosome, and blocking canonical apoptosis in a homozygous state. The mosaic eyes exhibit defects in eye development including patches of rough eye and irregular surface structure.
View Article and Find Full Text PDFDermal exposure and hair dye: Assessing potential bladder cancer risk from permanent hair dye.
Regul Toxicol Pharmacol
February 2023
Article Synopsis
- Hair dye products contain various chemicals, with para-phenylenediamine (PPD) being a common compound used to create a permanent effect; 4-aminobiphenyl (4-ABP) is often a trace contaminant associated with PPD and has been labeled a carcinogen by several regulatory agencies.
- The Office of Environmental Health Hazard Assessment (OEHHA) determined a cancer risk value for 4-ABP based on animal studies, and estimates of daily exposure to 4-ABP from hair dye application ranged dramatically, suggesting varying levels of risk.
- The findings indicate that there's no significant increased risk of bladder cancer for consumers using permanent hair dye with 4-ABP, particularly because the likelihood
A critical review of methods for decontaminating filtering facepiece respirators.
Toxicol Ind Health
September 2020
Various decontamination methods that may be used to extend respirator inventories have been examined for over a decade. In light of the ongoing coronavirus disease 2019 pandemic, many health-care settings are now implementing these techniques amid respirator shortages. We sought to perform a critical review of the available literature regarding decontamination methods to determine which strategies are effective at inactivating the target organism, preserve performance (filter efficiency and fit) of the respirator, leave no residual toxicity from the treatment, and are fast-acting, inexpensive, and readily available.
View Article and Find Full Text PDFBackground: Para-Phenylenediamine (PPD) is a commonly used dye intermediate in permanent hair dye formulations, and exposure to PPD has been associated with allergic contact dermatitis at certain doses.
Purpose: Determine the concentration of PPD in a survey of self-application permanent hair dye products, and perform a quantitative risk assessment to determine the risk of skin sensitization induction following application of these products.
Methods: Consumer exposure levels (CELs) to PPD following application of hair dye products were estimated using the maximum amount of hair dye that can adhere to the surface area of the scalp, the measured concentration of PPD in the hair dye product, a retention factor, the dermal absorption of PPD, and the surface area of the scalp.