Publications by authors named "D M Henke"
Objectives: In cancer studies, assessment of patients' physical function can provide insight into cancer-related symptoms and the side effects of treatment. Physical function can be assessed using patient-reported outcome measures (PROMs), which may or may not include a recall period-the amount of time the questionnaire asks the respondent to think back to answer the questions. More understanding is needed about how patients interpret and respond to items posed with different recall periods, and which recall period they actually use.
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- RSV is more severe in infants than in adults, but the reasons for this difference are not fully understood.
- Researchers used nasal organoid models from both infants and adults to explore how their nasal linings respond to RSV infection.
- The study found that infant nasal cells had a stronger viral response, more mucus production, and greater cell damage, suggesting that infants’ immune responses might lead to more severe infections than in adults.
Article Synopsis
- - Respiratory syncytial virus (RSV) and human noroviruses (HuNoV) are major pathogens that cause respiratory and gastrointestinal infections respectively, making it essential to generate full-length genome sequences for studying their diversity and tracking variants.
- - The study developed oligonucleotide probe sets from numerous viral isolate sequences, which were utilized in a capture enrichment sequencing workflow to analyze samples, significantly improving the quality of viral genome recovery.
- - The results showed that over 99% of RSV genomes and over 96% of HuNoV genomes were complete post-capture, demonstrating the effectiveness of this method for comprehensive genome sequencing and monitoring emerging variants.
Article Synopsis
- Viral infections involve diverse viral genomes, and high-throughput sequencing can help study these populations, though few examples exist.
- This study uses advanced sequencing on nasal wash samples from hematopoietic cell transplant recipients with RSV to analyze genomic and transcriptomic data separately.
- Findings indicate low genetic variation in RSV infections, but reveal differences between genomes and transcripts in genetic diversity, variation hotspots, and alternative amino acid encoding, highlighting the need for separate analyses in viral research.
Purpose: Performance status is an important concept in oncology, but is typically clinician-reported. Efforts are underway to include patient-reported measures in cancer care, which may improve patient symptoms, quality of life and overall survival. The purpose of this study was to gain a preliminary understanding of how patients determined their physical performance status based on a novel patient-reported version of the Eastern Cooperative Oncology Group Performance Status (ECOG) scale.
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