Publications by authors named "D M Hedderich"
Background: The aim of this study was to determine the influence of intraoral reconstructions following oral squamous cell carcinoma (OSCC) resection with a free microvascular flap on the posterior airway space (PAS) and to correlate these results with the potential risk of developing an obstructive sleep apnea syndrome (OSAS).
Materials And Methods: Only primary OSCC cases of the tongue or floor of the mouth which were operated and reconstructed. The PAS displayed in computed tomography (CT) scans at three time points were analyzed: t = preoperative, t = first postoperative CT, and t = most recent situation.
Article Synopsis
- - Despite significant research on the claustrum's role in the mammalian brain, studies on its connections in humans are limited due to its complex anatomy and challenges in imaging techniques.
- - The study used deep-learning segmentation and diffusion-weighted imaging (DWI)-based tractography on two large groups of healthy adults to explore claustrum connectivity.
- - Results showed consistent and replicable connections between the claustrum and various brain regions across different subjects, enhancing the understanding of claustrum connectivity and its implications for health and disease.
Uncovering genetic mimics in multiple sclerosis: A single-center clinical exome sequencing study.
Mult Scler J Exp Transl Clin
July 2024
Background: Multiple sclerosis (MS) shares clinical/radiological features with several monogenic diseases that can mimic MS.
Objective: We aimed to determine if exome sequencing can identify monogenic diseases in patients diagnosed with MS according to the McDonald criteria thus uncovering them as being misdiagnosed.
Methods: We performed whole exome sequencing in a cohort of 278 patients with MS, clinically or radiologically isolated syndrome without cerebrospinal fluid-specific oligoclonal bands (CSF-OCBs) (n = 228), a positive family history of MS (n = 44), or both (n = 6), thereby focusing on individuals potentially more likely to have underlying monogenic conditions mimicking MS.
Lasting thalamus volume reduction after preterm birth is a prominent finding. However, whether thalamic nuclei volumes are affected differentially by preterm birth and whether nuclei aberrations are relevant for cognitive functioning remains unknown. Using T1-weighted MR-images of 83 adults born very preterm (≤ 32 weeks' gestation; VP) and/or with very low body weight (≤ 1,500 g; VLBW) as well as of 92 full-term born (≥ 37 weeks' gestation) controls, we compared thalamic nuclei volumes of six subregions (anterior, lateral, ventral, intralaminar, medial, and pulvinar) across groups at the age of 26 years.
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