Publications by authors named "D M Hallam"
Article Synopsis
- Biallelic mutations in the DRAM2 gene cause a form of vision loss called CORD21, which usually shows up between ages 30 and 60.
- Researchers studied retinal organoids and retinal pigment epithelium (RPE) cells from patients with CORD21 to understand the gene's role in retinal degeneration.
- They discovered that DRAM2 is involved in lipid metabolism, lysosomal function, and cellular processes, indicating its importance for the health of photoreceptors and RPE cells.
Hereditary hemorrhagic telangiectasia (HHT) is a disorder that affects 1 in 5000-10,000 people worldwide and can result in devastating complications such as cerebral abscess, stroke, massive hemorrhage, and even death. HHT is an autosomal dominant disorder that leads to the formation of abnormal communication between the arteries and veins with a resultant spectrum of vascular anomalies. The disorder affects many organ systems and thus requires a dedicated multidisciplinary approach.
View Article and Find Full Text PDFBackground: Spinal cerebrospinal fluid venous fistula (CVF) is a recognized cause of chronic positional headache and spontaneous intracranial hypotension (SIH). It occurs due to an aberrant connection formed between the spinal subarachnoid space and an adjacent spinal epidural vein. The diagnosis of CVF can be difficult to establish but can be documented utilizing advanced imaging techniques (e.
View Article and Find Full Text PDFBackground: Stent-assisted coiling of wide-necked intracranial aneurysms (IAs) using the Neuroform Atlas Stent System (Atlas) has shown promising results.
Objective: To present the primary efficacy and safety results of the ATLAS Investigational Device Exemption (IDE) trial in a cohort of patients with posterior circulation IAs.
Methods: The ATLAS trial is a prospective, multicenter, single-arm, open-label study of unruptured, wide-necked, IAs treated with the Atlas stent and adjunctive coiling.
Article Synopsis
- The study investigates the effectiveness and safety of mechanical thrombectomy in children who have suffered a stroke, aiming to address concerns about inconsistent reporting in existing literature.
- It compares clinical data from 42 children treated at specific study sites with 133 cases documented in published reports, focusing on the National Institutes of Health Stroke Scale scores before and after treatment.
- Findings reveal that study site patients had more complete reporting of stroke severity, but they also experienced worse short-term outcomes compared to those reported in literature cases.