Publications by authors named "D M Gold"
Article Synopsis
- The Vitamin D Antenatal Asthma Reduction Trial (VDAART) studied children from 6 months to 8 years and found links between specific gene variants and children's body mass index.
- These associations also connected microbiome characteristics tied to obesity with important lipids and amino acids.
- The findings suggest that genetic factors play a role in influencing the microbiome during development and highlight potential biomarkers for childhood obesity and related health issues like insulin resistance and type 2 diabetes.
Background: Higher soluble urokinase plasminogen activator receptor (suPAR) levels are associated with adverse outcomes in chronic heart failure (HF).
Objectives: The authors assessed the association between proteomics-based suPAR levels and incident HF risk in the general population.
Methods: In 40,418 UK Biobank participants without HF or coronary artery disease at enrollment, the association between Olink-based suPAR levels measured as relative protein expression levels and incident all-cause, ischemic, and nonischemic HF was analyzed by competing-risk regression, while accounting for all-cause death as a competing risk.
Background: PFAS may impair bone health, but effects of PFAS exposure assessed during pregnancy and the perimenopause-life stages marked by rapidly changing bone metabolism-on later life bone health are unknown.
Methods: We studied 531 women in the Boston-area Project Viva cohort. We used multivariable linear, generalized additive, and mixture models to examine associations of plasma PFAS concentrations during early pregnancy [median (IQR) maternal age 32.
Comparison of Race-neutral Versus Race-specific Spirometry Equations for Evaluation of Child Asthma.
Am J Respir Crit Care Med
December 2024
Rationale: Race-based estimates of pulmonary function in children could influence the evaluation of asthma in children from racial and ethnic minoritized backgrounds.
Objectives: To determine if race-neutral (GLI-Global) versus race-specific (GLI-Race-Specific) reference equations differentially impact spirometry evaluation of childhood asthma.
Methods: The analysis included 8,719 children aged 5 to <12 years from 27 cohorts across the United States grouped by parent-reported race and ethnicity.