Publications by authors named "D M Gimenez Cervantes"
Allergic asthma is characterized by increased type 2 inflammation, including eosinophils. Subjects with allergic asthma have recurrent symptoms due to their constant exposure to environmental allergens, such as house dust mite (HDM), which can be further exacerbated by respiratory infections like rhinovirus. The immunoproteasome (IP) is a proteolytic machinery that is induced by inflammatory mediators during virus infection, but the role of the IP in airway allergic inflammation during rhinovirus infection remains unknown.
View Article and Find Full Text PDFThe Infection Control Advocate and Resident Education educational modules integrate and promote infection prevention and control (IPC) measures and residents' rights in nursing homes, targeting long-term care ombudsmen, residents, families, and other resident advocates. Survey respondents (N = 102) reported increased knowledge in understanding IPC and preserving resident rights. Integrating these topics and identifying barriers to promoting IPC is necessary for implementing quality IPC in nursing homes.
View Article and Find Full Text PDFChronic diseases continue to rise among African American women making lifestyle programs a critical aspect of risk reduction and disease prevention. Weight management programs often have a reduced impact among African American women compared to White women, in part due to interactions between individual, social, and environmental factors. A secondary analysis of focus group data evaluated how cultural elements and contextual factors identified by church-going African American women influence intervention design, approaches for cultural adaptation, and solutions to weight management.
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- Metabolic syndrome increases the risk of coronary artery disease and affects heart function, which was studied in female mice fed a Western diet compared to those on regular chow.
- Mice on the Western diet showed increased body weight and left ventricular mass but maintained systolic and diastolic function, alongside reduced heart rate variability indicating altered cardiac balance.
- Myocytes from these mice exhibited changes in size and mechanics, with heightened cAMP and PKA activity; interventions affecting this pathway improved their function, suggesting adaptations to maintain heart performance despite diet-induced metabolic issues.
Background: Influenza A virus (IAV) infection is a significant risk factor for respiratory diseases, but the host defense mechanisms against IAV remain to be defined. Immune regulators such as surfactant protein A (SP-A) and Toll-interacting protein (Tollip) have been shown to be involved in IAV infection, but whether SP-A and Tollip cooperate in more effective host defense against IAV infection has not been investigated.
Methods: Wild-type (WT), Tollip knockout (KO), SP-A KO, and Tollip/SP-A double KO (dKO) mice were infected with IAV for four days.