Publications by authors named "D M Gagliano"
Objective: to study the anatomical feasibility of laser fiber insertion for interstitial thermal therapy via transorbital approach to the temporo-mesial structures (amygdala-hippocampus-parahippocampus complex).
Methods: Anatomical dissections were performed bilaterally on two human cadaveric heads via a transorbital approach, in which screws and laser fibers were used for magnetic resonance imaging-guided laser interstitial thermal therapy (MRIgLITT) assisted by neuronavigation. In addition, eight transorbital trajectories were simulated using the transorbital entry points obtained from a cadaveric radiological study of four patients previously operated on for mesial temporal lobe epilepsy.
Article Synopsis
- The study investigates the transorbital approach (TO) for accessing vascular lesions, specifically the carotid and middle cerebral arteries, using cadaveric specimens to understand its feasibility for vascular clipping.
- Dissection involved a stepwise TO method that included procedures like lateral orbital craniectomy and anterior clinoidectomy, allowing for exposure of various vascular segments and cranial nerves.
- Findings suggest that the TO approach effectively exposes key artery segments, indicating its potential use in treating paraclinoid and posterior communicating aneurysms.
To analyze the efficacy and safety of surgery compared to radiosurgery (RS), combined or not with whole brain radiotherapy (WBRT), for localized metastatic brain disease. A systematic review with meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The inclusion criteria were limited to randomized controlled trials (RCTs) that compared surgery and RS for patients with up to 3 metastases (median diameter ≤ 4 cm).
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