Publications by authors named "D M Dhavale"
Article Synopsis
- TDP-43 is an RNA binding protein that forms aggregates in the central nervous system and is notably present in certain neurodegenerative diseases and inclusion body myopathy, a type of muscle disease.
- Researchers developed a mouse model that shows muscle weakness associated with TDP-43 accumulation, which indicates a prion-like spread of the protein possibly affecting muscle tissues.
- Human muscle biopsies from patients with various conditions, especially inclusion body myositis (IBM), contain TDP-43 aggregate seeds, suggesting a unique pathogenic role for TDP-43 in muscle diseases that wasn't fully recognized before.
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein that accumulates as aggregates in the central nervous system of some neurodegenerative diseases. However, TDP-43 aggregation is also a sensitive and specific pathologic feature found in a family of degenerative muscle diseases termed inclusion body myopathy (IBM). TDP-43 aggregates from ALS and FTD brain lysates may serve as self-templating aggregate seeds and supporting a prion-like spread from cell to cell.
View Article and Find Full Text PDFLysosomal membrane permeabilization caused either via phagocytosis of particulates or the uptake of protein aggregates can trigger the activation of NLRP3 inflammasome- an intense inflammatory response that drives the release of the pro-inflammatory cytokine IL-1β by regulating the activity of CASPASE 1. The maintenance of lysosomal homeostasis and lysosomal membrane integrity is facilitated by the AAA+ ATPase, VCP/p97 (VCP). However, the relationship between VCP and NLRP3 inflammasome activity remains unexplored.
View Article and Find Full Text PDFArticle Synopsis
- * The researchers developed a new method to enhance the extraction of these alpha-synuclein fibrils from postmortem tissue, using solid state nuclear magnetic resonance (SSNMR) to analyze their atomic structure.
- * Their findings reveal that the fibrils from Lewy body dementia consist of both single and double protofilaments, and display structural similarities to previously studied twisted fibrils; this could aid in understanding disease mechanisms and developing new treatments.
Article Synopsis
- Fibrils of the protein α-synuclein are linked to several neurodegenerative diseases, including Parkinson's Disease and Lewy Body Dementia.
- Researchers have utilized solid-state NMR methods to analyze various forms of α-synuclein fibrils and previously published resonance assignments.
- This study introduces a new set of carbon and nitrogen assignments specific to fibrils derived from the postmortem brain tissue of a Lewy Body Dementia patient.