Publications by authors named "D M DeMarini"
Mutagenic Atmospheres Generated from the Photooxidation of NO with Selected VOCs and a Complex Mixture: Apportionment of Aromatic Mutagenicity for Reacted Gasoline Vapor.
Atmos Environ (1994)
June 2024
Article Synopsis
- The study investigates how sunlight interacts with volatile organic compounds (VOCs), particularly those from gasoline vapors, producing harmful byproducts that contribute to air pollution.
- Researchers found that atmospheres created by irradiating gasoline and certain non-aromatic VOCs were mutagenic, meaning they could potentially cause genetic mutations, while dark atmospheres were not.
- The findings suggest that while non-aromatic VOCs have a minor role in mutagenicity, combined with aromatic VOCs, they can account for a significant portion of the mutagenic effects of gasoline vapors, highlighting the need for emission reduction strategies to improve air quality and public health.
Molecular Compositions, Mutagenicity, and Mutation Spectra of Atmospheric Oxidation Products of Alkenes and Dienes Initiated by NOx + UV or Ozone: A Structure-Activity Analysis.
Environ Sci Technol
October 2024
Photooxidation products resulting from volatile organic compounds (VOCs) reacting with sunlight are important contributors to gas-phase air pollution. We characterized the product-weighted mutagenic potencies (rev m mgC h) in TA100 of atmospheres resulting from the hydroxyl radical (OH)-initiated photochemical oxidation of 11 C or C alkenes or dienes in the presence of nitric oxide (NO) and from the ozonolysis of four VOCs without NO (isoprene; 1,3-pentadiene; 1,4-pentadiene; and 1,3-butadiene). Irradiated atmospheres from precursors with a single C═C bond (3-methyl-1-butene, 2-methyl-1-butene, -2-pentene, 2-methyl-2-butene, 1-butene, and 1-pentene) had low potencies (<5), whereas linear dienes with terminal C═C bonds had high potencies (50-65).
View Article and Find Full Text PDFThe etiology of bladder cancer among never smokers without occupational or environmental exposure to established urothelial carcinogens remains unclear. Urinary mutagenicity is an integrative measure that reflects recent exposure to genotoxic agents. Here, we investigated its potential association with bladder cancer in rural northern New England.
View Article and Find Full Text PDFAs part of an analysis performed under the auspices of the International Workshop on Genotoxicity Testing (IWGT) in 2017, we and others showed that Salmonella frameshift strain TA98 and base-substitution strain TA100 together + /- S9 detected 93% of the mutagens detected by all the bacterial strains recommended by OECD TG471 (Williams et al., Mutation Res. 848:503081, 2019).
View Article and Find Full Text PDFBackground: Parsaclisib, a potent and highly selective PI3Kδ inhibitor, has shown clinical benefit in patients with relapsed or refractory (R/R) B-cell malignancies. This phase 2 study (CITADEL-203; NCT03126019, EudraCT 2017-001624-22) assessed efficacy and safety of parsaclisib monotherapy in patients with R/R follicular lymphoma (FL).
Methods: Patients ≥18 years of age with histologically confirmed R/R FL (grade 1-3a) and prior treatment with ≥2 systemic therapies received parsaclisib 20 mg once daily (QD) for 8 weeks then parsaclisib 20 mg once weekly (weekly dosing group [WG]) or parsaclisib 20 mg QD for 8 weeks then parsaclisib 2.