Publications by authors named "D M Danos"
Background: Liver cancer incidence and mortality have been shown to differ by race, ethnicity, and geography. This study aims to analyze disparities in the multimodal treatment of liver cancers in Louisiana.
Methods: Cases of nonmetastatic liver cancer in Louisiana from 2010 to 2020 were obtained from the Louisiana Tumor Registry.
Background: This study aims to identify factors associated with disparities in receipt and outcomes of surgical interventions in patients with primary nonmetastatic liver cancers.
Methods: Cases from 2010 to 2020 were identified using Louisiana Tumor Registry. Four surgical categories were utilized: none, ablation, resection, transplant.
Article Synopsis
- Potassium ions (K) play a crucial role in regulating functions of immune cells, with increased extracellular potassium in tumors hindering T cell activity and suppressing macrophage function.
- This study reveals that elevated potassium chloride (KCl) boosts autophagy in myeloid-derived suppressor cells (MDSCs) by increasing autophagosome marker LC3β while decreasing certain immune suppressive enzymes like arginase I and iNOS.
- The findings also indicate that excess potassium alters key signaling pathways and enhances mitochondrial respiration in MDSCs, which is critical for their immunosuppressive role, providing insights for potential therapies targeting MDSCs in cancer treatment.
Article Synopsis
- The study investigated the impact of cardiopulmonary resuscitation (CPR) on brain and skin oxygen levels in pigs experiencing severe hemorrhagic shock, a condition where blood pressure drops critically.
- Using a controlled experiment with 12 swine, results indicated that while CPR increased systolic blood pressure, it did not improve overall tissue oxygenation and, in fact, reduced skin perfusion significantly.
- The findings support previous research suggesting that CPR may not benefit organ oxygenation during hemorrhagic shock and could even have harmful effects.
Introduction: Previous studies have demonstrated worse outcomes for Hirschsprung's disease (HD) procedures in Trisomy 21 (T21) patients. Using a large national database, we sought to investigate surgical outcomes in HD patients with T21 compared to non-T21 patients.
Methods: We utilized the deidentified National Surgical Quality Improvement Program Pediatric database from 2012 to 2021.