Obturator Neurectomy for the Treatment of Adductor Spasticity: A Novel Technique and Case Series.

Background The management of adductor spasticity and long-term sequelae for cerebral palsy (CP) patients is complex. Hip displacement is a common consequence of CP, and obturator neurectomy (ON) is a potentially underutilized procedure to address the underlying adductor spasticity. The aim of this study is to describe the operational technique of ON and highlight the potential efficacy of ON in reducing spasticity, as well as pain, hip, and functional outcomes in these patients.

Seminal Vesiculitis: A Rare Cause of Unilateral Ureteric Obstruction.

The seminal vesicles are an accessory structure of the male reproductive system. The most common pathology associated with the seminal vesicles is infective, and patients may present with haematospermia, pain, and subfertility. Patients presenting with unilateral ureteric obstruction secondary to seminal vesiculitis are rare, and there are very few reported cases in the literature.

Mitigating Effects of Packet Loss in Wireless Neural Data Transfer: Exploring the Influence of Low-Cost Recovery Methods on Spikes and HFOs in iEEG.

The wireless transmission of neural data may pose the risk of packet loss (PL), potentially compromising signal quality or, in extreme cases, causing complete data loss. Addressing lost packets is essential to ensure data integrity and preserve vital neural patterns. This study investigates the effect of PL interference on epilepsy neuro biomarkers, focusing specifically on interictal epileptiform spikes and high frequency oscillations (HFOs), and the performance of the low computational cost interpolation methods.

Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell types.

The development of cell-type-specific gene therapy vectors for treating neurological diseases holds great promise, but has relied on animal models with limited translational utility. We have adapted an organotypic model to evaluate adeno-associated virus (AAV) transduction properties in living slices of human brain tissue. Using fluorescent reporter expression and single-nucleus RNA sequencing, we found that common AAV vectors show broad transduction of normal cell types, with protein expression most apparent in astrocytes; this work introduces a pipeline for identifying and optimizing AAV gene therapy vectors in human brain samples.