Publications by authors named "D M Bulach"
Lumpy skin disease (LSD) in cattle is managed through live-attenuated vaccines. Bangladesh LSD vaccine was developed from LSD virus isolate Bangladesh LSD-29 by passaging 60 times in cell culture. Here, we report the complete genome sequence of Bangladesh LSD vaccine strain.
View Article and Find Full Text PDFLumpy skin disease (LSD) is an economically devasting and vector-borne transboundary disease of cattle caused by lumpy skin disease virus (LSDV). Here, we report the complete genome sequence of an outbreak isolate of LSDV from Bangladesh. Bangladesh LSD-29 was detected in skin nodule samples of an LSD-infected bovine in 2021.
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- The study focuses on a strain of bacteria, considered normal flora, that can lead to diarrhea, highlighting its ability to invade cells and cause illness in animal models.
- Researchers sequenced both the parent strain and its mutants to identify genetic changes that influenced virulence, specifically looking at transposon (Tn) insertion sites.
- The findings reveal that a Tn insertion in the plasmid's type three secretion system (T3SS) is crucial for the bacteria's ability to cause diarrhea, marking a subgroup with this plasmid as a potential enteric pathogen.
Article Synopsis
- Campylobacter spp. are a leading cause of bacterial gastroenteritis in Australia, often linked to contaminated meat, with a study exploring the relationship between genomic virulence characteristics and the severity of the illness.
- The research included 571 campylobacteriosis cases, revealing that symptoms typically last about 7.5 days and vary in severity based on age and pre-existing health conditions, with older patients exhibiting milder symptoms but higher hospitalization rates.
- Although the study found many virulence genes present in the bacteria, they did not correlate with illness severity; instead, age and comorbidities were identified as the primary factors influencing health outcomes.
is a multidrug-resistant nosocomial pathogen that colonizes and infects debilitated patients in the ICU. There is very little information on the genomic characteristics of colonizing strains. This information is important to understand the evolution of lineages of that develop resistance while patients receive antibiotic treatment in the ICU.
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