Publications by authors named "D M Bryant"
Motivation: Fluorophore-assisted seed amplification assays (F-SAAs), such as real-time quaking-induced conversion (RT-QuIC) and fluorophore-assisted protein misfolding cyclic amplification (F-PMCA), have become indispensable tools for studying protein misfolding in neurodegenerative diseases. However, analyzing data generated by these techniques often requires complex and time-consuming manual processes. Additionally, the lack of standardization in F-SAA data analysis presents a significant challenge to the interpretation and reproducibility of F-SAA results across different laboratories and studies.
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- - The study aimed to develop accessible educational programs for shoulder replacement surgery by understanding the preferences of patients and healthcare providers regarding content and educational devices.
- - Interviews with 10 patients and 9 healthcare providers identified four key themes: how to access information, what educational content to include, decisions around device use, and factors influencing patient engagement.
- - Both patient and clinician participants preferred a comprehensive education program combining a website with videos and a written booklet covering crucial topics like surgery info, recovery timelines, and post-operative expectations to enhance patient satisfaction.
Sensitive and specific antemortem diagnostic tests are a prerequisite for effective management of chronic wasting disease (CWD). Paired with readily accessible samples that accurately reflect CWD status, the real-time quaking-induced conversion (RT-QuIC) assay has the potential to enable more effective CWD surveillance and interventions. We evaluated the feasibility of RT-QuIC as a CWD diagnostic test using 6-mm ear tissue biopsies from elk (Cervus canadensis).
View Article and Find Full Text PDFPurpose: The new CAP guideline published in August 2022 recommends using immunohistochemistry (IHC) to test for mismatch repair defects in gastroesophageal (GE), small bowel (SB), or endometrial carcinoma (EC) cancers over next-generation sequencing assessment of microsatellite instability (NGS-MSI) for immune checkpoint inhibitor (ICI) therapy eligibility and states there is a preference to use IHC over NGS-MSI in colorectal carcinoma (CRC).
Methods: We assessed the concordance of NGS-MSI and IHC-MMR from a very large cohort across the spectrum of solid tumors.
Results: Of the over 190,000 samples with both NGS-MSI and IHC-MMR about 1,160 were initially flagged as discordant.
Article Synopsis
- * Surplus bread crusts can effectively act as a structure for SSF, and when combined with perennial ryegrass, they enhance each other’s nutritional profiles.
- * The study using Rhizopus oligosporus showed significant reductions in starch and increases in amino acids, suggesting that this method can turn underutilized bread crusts and ryegrass into valuable sources of alternative protein.