Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations, most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage through mechanisms that remain unclear. To gain insight into how CH mutations enable gradual clonal expansion, we used single-cell multi-omics with high-fidelity genotyping on human CH bone marrow (BM) samples. Most of the selective advantage of mutant cells occurs within HSCs.

Trunk and hip muscle activation during yoga poses: Do sex-differences exist?

Objective: To compare core activation during yoga between males and females.

Methods: Surface electromyography was used to quantify rectus abdominis (RA), abdominal obliques (AO), lumbar extensors (LE), and gluteus maximus (GMX) activation during four yoga poses. Data were expressed as 100% of a maximum voluntary isometric contraction.

Trunk and hip muscle activation during yoga poses: Implications for physical therapy practice.

Objective: To determine and compare activation of core muscles during yoga to traditional back exercises.

Methods: Surface electromyography was used to quantify activation of the rectus abdominis (RA), abdominal obliques (AO), lumbar extensors (LE), and gluteus maximus (GMX) during four yoga poses. Data were expressed as 100% of a maximum voluntary isometric contraction.

Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial.

Objective: We sought to determine the effect of supplemental antioxidant vitamins C and E on the rate of preeclampsia in high-risk pregnant women.

Study Design: Women at risk for preeclampsia (previous preeclampsia, chronic hypertension, pregestational diabetes, or multifetal gestation) were recruited at 14 to 20 weeks' gestation and randomly assigned to receive either 1000 mg of vitamin C and 400 IU of vitamin E or placebo daily in addition to their regular prenatal vitamins. The primary outcome was the occurrence of preeclampsia.

Relationship of prenatal care and perinatal morbidity in low-birth-weight infants.

Objective: Lack of or no prenatal care (NPC) is associated with preterm birth (PTB) and low birth weight (LBW). Our purpose was to determine whether LBW infants delivered after NPC have worse outcomes than LBW infants with prenatal care (PC).

Study Design: Eight thousand sixty-five consecutive women delivered at six hospitals in Shelby County, Tenn, were evaluated regarding clinical characteristics and perinatal outcomes depending on the occurrence of PC.