Publications by authors named "D M Barrios"
Article Synopsis
- DESTINY-CRC01 was a multicenter phase 2 study examining the safety and effectiveness of trastuzumab deruxtecan (T-DXd) in patients with HER2-positive metastatic colorectal cancer.
- The exploratory biomarker analysis identified correlations between higher HER2 biomarker levels and improved clinical outcomes, such as response rate and overall survival, in patients with HER2-positive tumors.
- Circulating tumor DNA analysis indicated that T-DXd may also be effective in patients with specific genetic mutations (RAS, PIK3CA, or HER2) detected in their ctDNA.
Purpose: This multicenter phase Ib study investigated trastuzumab deruxtecan (T-DXd) plus nivolumab in patients with HER2-expressing metastatic breast cancer (mBC) and metastatic urothelial cancer (mUC).
Patients And Methods: Part 1 determined the recommended dose for expansion of T-DXd plus nivolumab. Part 2 evaluated efficacy and safety; the primary endpoint was confirmed objective response rate by independent central review.
Teaching medical rounds in intensive care units (ICUs) are essential for resident education. However, the ICU's high workload can hinder these rounds. We propose a new approach that is based on the constructivist theory of learning communities.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined the antibody responses of 31 healthy adults over two years following COVID-19 vaccination, revealing significant differences in antibody kinetics for IgM, IgA, and IgG types, with IgG levels decaying slowly and IgM levels dropping rapidly after vaccination.
- - Three booster doses of the vaccine increased and prolonged the levels of anti-spike IgG and IgA antibodies, while infection produced the highest antibody peak and slowest decay, compared to the two-dose regimen.
- - The research found that antibody levels against Omicron variants decreased more quickly than those against the original virus, and that strong T-cell responses were linked to enhanced IgA production.