An Analysis of the Impact of a Multimodal Therapy Order Set on Post-Operative Opioid Prescribing After Orthopedic Shoulder Procedures.

Background: Opioids are effective for post-operative pain control but are no longer considered appropriate as the sole method for managing pain after surgery. Newer, multimodal approaches to pain control are increasingly being employed to decrease reliance on opioids, but patient-related outcomes are not consistently reported with these interventions.

Objective: This study evaluated the effect of implementing a new multimodal therapy order set, coupled with new patient education materials, on post-operative outcomes after complex shoulder surgery.

Systemic coordination of whole-body tissue remodeling during local regeneration in sea anemones.

The complexity of regeneration extends beyond local wound responses, eliciting systemic processes across the entire organism. However, the functional relevance and coordination of distant molecular processes remain unclear. In the cnidarian Nematostella vectensis, we show that local regeneration triggers a systemic homeostatic response, leading to coordinated whole-body remodeling.

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response.

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this, yet coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding.