Basic Science and Pathogenesis.

Background: Hallmark pathologies of Alzheimer's Disease (AD) include the accumulation of both extracellular amyloid and intracellular tau proteins. While a significant body of knowledge exists surrounding the role of the protein aggregates in the context of AD, research supporting these as targets for therapeutic development have yielded inconsistent findings. One significant barrier is the inability to restore cognitive function despite the successful clearance of these proteins.

Football (soccer) match-derived hamstring muscles residual fatigue can be monitored using early rate of torque development.

Purpose: The aim of this study was to determine whether a soccer match affects the rapid force-generating capacity of the hamstring muscles, given their key role in both horizontal ground reaction force production during sprint biomechanics, and in the deceleration of the shank during the late swing phase, where rapid force production is essential owing to time constraints. Therefore, the research objective was to determine soccer match-induced hamstrings residual fatigue and recovery through rate of torque development (RTD) and associated biochemical parameters.

Methods: The recovery kinetics of hamstrings RTD metrics by the 90°:20° test, together with serum biomarkers (creatine kinase, mitochondrial creatine kinase, transaminases, malondialdehyde, irisin), were assessed in 19 male, regional first-division soccer players (age = 20.

Biomechanical Implications of Asymmetric Gardner-Wells Tong Placement During Cervical Spine Traction.

In cases of cervical facet dislocations, traction is typically delivered in the acute setting with tongs attached to the skull via two pins. Although the pins are recommended to be inserted symmetrically in a neutral loading position, erroneous asymmetric pin placement has been documented in case reports, but its biomechanical implications are unknown. The current study utilized a human surrogate to evaluate the influence of asymmetrically placed pins in the axial or frontal planes.

Chemical probes for the identification of the molecular targets of honokiol.

Honokiol is a natural product with an interesting array of biological effects, including significant anti-tumor properties. However, full exploration of its therapeutic potential is hampered by its modest pharmacokinetic profile and by the lack of synthetic methods that allow to obtain specifically designed derivatives with improved properties. In addition, the specific molecular targets of honokiol remain poorly understood, a fact that limits the search of alternative hits for subsequent optimization programs.