Evaluation of extruded starch foam for glucose-supplying biomaterials.

The survival rate of mesenchymal stem cells (MSC), a crucial factor in tissue engineering, is highly dependent on glucose supply. The purpose of this paper is to study the potential of starch foams as glucose suppliers. It is investigated through in vitro hydrolysis by amyloglucosidase in conditions that respect physiological constraints (37 °C and pH 7.

Monitoring of water sorption and swelling of potato starch-glycerol extruded blend by magnetic resonance imaging and multivariate curve resolution.

Magnetic resonance microimaging (MRμI) is an outstanding technique for studying water transfers in millimetric bio-based materials in a non-destructive and non-invasive manner. However, depending on the composition of the material, monitoring and quantification of these transfers can be very complex, and hence reliable image processing and analysis tools are necessary. In this study, a combination of MRμI and multivariate curve resolution-alternating least squares (MCR-ALS) is proposed to monitor the water ingress into a potato starch extruded blend containing 20% glycerol that was shown to have interesting properties for biomedical, textile, and food applications.

Melt processing of paramylon using a water:ionic liquid mixture as plasticizer.

Paramylon is a linear β-1,3-glucan produced by the microalgae Euglena Gracilis. Due to its native crystalline structure, involving hexagonally packed triple helices, paramylon is neither water soluble nor thermoplastic. While such properties are generally obtained by chemical modification of paramylon, the present work demonstrates that using ionic liquid/water mixtures as solvents or plasticizers may be an alternative: A mixture of water with cholinium glycinate (40:60) allowed: i) obtaining paramylon solutions at 80 °C, that form reversible ionogels upon cooling at 20 °C, when used as a solvent, and ii) the thermomechanical processing of paramylon below 100 °C by extrusion and hot-press into transparent films, when used as a plasticizer.

Release kinetics of [lidocainium][ibuprofenate] as Active Pharmaceutical Ingredient-Ionic Liquid from a plasticized zein matrix in simulated digestion.

An in vitro approach is proposed to study the release of an Active Pharmaceutical Ingredient-Ionic Liquid (API-IL) from a natural biopolymer matrix based on zein, a maize storage protein. Zein can be processed in the molten state with 20 w% [Lidocainium][Ibuprofenate] added as API-IL also acting as plasticizer and potentially co-plasticized by glycerol. The thermal stability of the matrix is checked, as well as the in vivo biological activity of the API-IL confirming anesthetic and anti-inflammatory activities.