Publications by authors named "D Lonati"
Background: Despite the importance of Ultrasound-guided Regional Anaesthesia (UGRA) in Emergency Medicine (EM), there is significant variability in UGRA training among emergency physicians. We recently developed a one-day (8 h), simulation-based UGRA course, specifically tailored to help emergency physicians to integrate these skills into their clinical practice.
Methods: In this pre/post intervention study, emergency physicians attended a course consisting of a 4-hour teaching on background knowledge and a practical part structured as follows: a scanning session on a healthy individual; a needling station with an ex-vivo model (turkey thighs); a simulation-based learning experience on local anaesthetic toxicity (LAST); a session on the UGRA simulator BlockSim™.
Ibuprofen, a commonly used over-the-counter medication, is widely recognized for its effective pain relief properties but is also associated with various adverse effects, including rare ocular and neurological manifestations. We report a case of a 27-year-old male who experienced transient vertical diplopia following a standard ibuprofen dosage for back pain. Symptoms resolved promptly upon discontinuation of the drug, with normal findings on extensive clinical and laboratory evaluations.
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- The study investigates the cytotoxic effects of methylglyoxal (MGO) on human-derived 3D neuronal spheroids, a model that mimics human brain cells, particularly in relation to aging and neurodegenerative diseases.
- Results show that MGO leads to decreased cell viability and growth at low concentrations, with significant cellular damage observed at higher doses, including necrosis and apoptosis.
- The findings highlight the potential of using these complex 3D models to evaluate the impact of MGO and other harmful agents, providing insights into mechanisms of neurodegeneration and aging.
Introduction: Some tobacco sticks, such as TEREA™ heat sticks for IQOS ILUMA™, contain a blade. Both the nicotine part of the device and the micro-blade can be ingested by children.
Case Summaries: We report two children, an 18-month-old boy and a 10-month-old girl, who ingested a heat stick containing a micro-blade.
Article Synopsis
- Lacosamide, a third-generation antiepileptic drug used for partial seizures, has had limited documentation of overdose cases since its approval in 2008, prompting a study to assess the clinical effects of acute poisoning.
- This retrospective study at the Pavia Poison Control Centre analyzed 31 cases between 2012 and 2021, noting that the median ingested dose was 1500 mg and that 64.5% of individuals had taken other substances like benzodiazepines.
- The findings indicated that 87% of patients experienced symptoms, with the most common being vomiting and seizures, and those who entered a coma had significantly higher doses; however, all patients eventually fully recovered