Publications by authors named "D Llobet"
Association between global platelet function and the risk of venous thromboembolic disease (VTE) has been proposed, though the mechanisms do not involve increased platelet aggregation. However, platelet adhesiveness has not been systematically explored in VTE patients. To evaluate platelet adhesive functions in VTE patients.
View Article and Find Full Text PDFBackground: Antithrombin, PC (protein C), and PS (protein S) are circulating natural anticoagulant proteins that regulate hemostasis and of which partial deficiencies are causes of venous thromboembolism. Previous genetic association studies involving antithrombin, PC, and PS were limited by modest sample sizes or by being restricted to candidate genes. In the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, we meta-analyzed across ancestries the results from 10 genome-wide association studies of plasma levels of antithrombin, PC, PS free, and PS total.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the relationship between levels of TMAO, γBB, and TML in patients with venous thromboembolism (VTE) versus healthy controls, involving 54 VTE patients and 57 controls.
- Results indicated no significant differences in the concentrations of these metabolites between the two groups, and while some correlations with thrombin generation parameters were observed, they were generally weak and unexpected.
- Overall, the findings suggest that TMAO and its derivatives do not play a strong role in VTE risk based on the measured concentrations.
Platelet hyperaggregability and venous thrombosis risk: results from the RETROVE project.
Blood Coagul Fibrinolysis
March 2021
The aim of the study was to determine whether platelet hyperaggregability correlates with short closure times (PFA-100) and if hyperaggregability is associated with the risk of venous thrombosis in a Spanish population. Case--control study (RETROVE project) involving 400 patients with venous thrombosis and 400 healthy controls. We determined platelet aggregation in platelet-rich plasma (PRP) by light transmission aggregometry.
View Article and Find Full Text PDFIntroduction: Platelet hyper-reactivity has been associated with thrombosis and high levels of human vesicle-associated membrane protein 8 (VAMP8) and serotonin transporter (SERT). Two polymorphisms (rs1010 of VAMP8 gene and in SERT gene (SLC6A4)) are associated with arterial thrombosis.
Aim: To determine if levels of serotonin, SERT and/or VAMP8 and these polymorphisms are associated with the risk of venous thrombosis.