Publications by authors named "D Lipka"
Article Synopsis
- MGMT silencing occurs in about 6-7% of pancreatic cancer (PAC) cases and is more common in tumors with non-ductal histology and KRAS wild type status.
- This silencing is linked to longer overall survival and is associated with fewer KRAS mutations, as well as immune exclusion features.
- The study suggests that MGMT-silenced PACs may respond better to treatments involving alkylating and DNA damaging agents, pointing to the potential for targeted therapy combinations.
Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between break point partners (motor neuron and pancreas homeobox 1 [MNX1] and ETS variant transcription factor 6 [ETV6]) has only been reported in a subset of cases. However, a universal feature is the strong transcript and protein expression of MNX1, a homeobox transcription factor that is normally not expressed in hematopoietic cells.
View Article and Find Full Text PDFFloating-Harbor syndrome (FHS) is an extremely rare genetic disorder connected with a distinctive facial appearance, various skeletal malformations, delayed bone age, and expressive language delays. It is caused by heterozygous mutations in the Snf2-related CREBBP activator protein (SRCAP) gene. The aim of this paper is to describe the case of a 14-year-old male with FHS, referring to a review of the literature, and to collect all reported symptoms.
View Article and Find Full Text PDFBackground: Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-programs the functions of neutrophils.
Methods: Ly6G-Cre JAK2-V617F and Ly6G-Cre CALRdel mice were generated.