Publications by authors named "D Limbrick"
Background: Post-hemorrhagic hydrocephalus (PHH) is a severe complication in premature infants following intraventricular hemorrhage (IVH). It is characterized by abnormal cerebrospinal fluid (CSF) accumulation, disrupted CSF dynamics, and elevated intracranial pressure (ICP), leading to significant neurological impairments.
Objective: This review provides an overview of recent molecular insights into the pathophysiology of PHH and evaluates emerging therapeutic approaches aimed at addressing its underlying mechanisms.
Purpose: This Hydrocephalus Clinical Research Network (HCRN) study had two aims: (1) to compare the predictive performance of the original ETV Success Score (ETVSS) using logistic regression modeling with other newer machine learning models and (2) to assess whether inclusion of imaging variables improves prediction performance using machine learning models.
Methods: We identified children undergoing first-time ETV for hydrocephalus that were enrolled prospectively at HCRN sites between 200 and 2020. The primary outcome was ETV success 6 months after index surgery.
Article Synopsis
- * After successful surgery to relieve pressure, the patient underwent treatment for SAH and showed significant improvement, with his symptoms resolving and no further complications over four years.
- * The report is significant as it presents the first known case of this type of hemorrhage following the surgery and suggests a potential relationship between syringomyelia and the diameter of the spinal canal.
Article Synopsis
- Shunt infections are a common issue in hydrocephalus treatment via CSF shunts, but the source of the pathogens remains unclear.
- A study examined 13 patients, comparing CSF samples from infection episodes with samples from earlier surgeries to explore if microorganisms existed before infection symptoms appeared.
- The results showed bacteria in 4 infection samples but none in prior samples, indicating a need for better detection methods and more research into potential infection sources like biofilms.