Effect of ascorbic acid (vitamin C) on the epiphyseal plate of young guinea pigs receiving prednisolone.

The effect of excess ascorbic acid on the epiphyseal plate of young guinea pigs receiving prednisolone over a period of 28 days has been investigated. The results show that the structural and morphologic changes caused in the epiphyseal plate of the animals receiving prednisolone are prevented by the simultaneous administration of excess ascorbic acid. These data are consistent with the hypothesis that pharmacological doses of ascorbic acid given concurrently to children receiving prolonged treatment with corticosteroids may prevent suppression of growth in these children.

Renal amyloidosis with nephrotic syndrome in a child suspected of having idiopathic pulmonary hemosiderosis.

A case of renal amyloidosis with nephrotic syndrome in a 12-year-old girl suffering from a chronic pulmonary disease is reported. Data from this patient's history, laboratory examination and radiographic evaluation of the pulmonary lesions favour the diagnosis of a long-standing idiopathic pulmonary hemosiderosis. A possible etiologic relationship between the pulmonary lesions and amyloid deposition in the kidney may be assumed.