Publications by authors named "D Lerche"

The characterization of dispersions, suspensions, and emulsions is important in a wide range of scientific applications and industries. Samples can consist of different materials and a wide range of particle sizes and concentrations. A single particle sizing and counting instrument with a dynamic detection range of ≥6 decades has been developed to detect single nano- and microparticles in aqueous suspensions based on light scattering measured in two directions.

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The aims of this study are to determine the oral health status of a rare sample of 19th-century migrant settlers to South Australia, how oral conditions may have influenced their general health, and how the oral health of this group compares with contemporaneous samples in Australia, New Zealand, and Britain. Dentitions of 18 adults and 22 subadults were investigated using non-destructive methods (micro-CT, macroscopic, radiographic). Extensive carious lesions were identified in seventeen adults and four subadults, and from this group one subadult and sixteen adults had antemortem tooth loss.

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Optical methods are appropriate for monitoring of constituents in suspensions and emulsions. A simple multi-wavelength, multi-reflectance spectroscopic technique, called MRS-Technology, is introduced. Two different signals of a sample are measured: the reflectance from a small and from a large measuring volume corresponding to the reduced scattering coefficient and to the sum of and the absorption coefficient μ, respectively.

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Background Total haemoglobin (Hb) concentration in blood belongs to the most requested measurands, and the HiCN method (hemiglobincyanide) is accepted as a reference. Although the reaction principle is clearly characterised, measurement conditions and settings are not consistently defined, some of them influencing the results. An improvement of standardisation is the object.

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Purpose: To optimize silica-iron oxide magnetic nanoparticles with surface phosphonate groups decorated with 25-kD branched polyethylenimine (PEI) for gene delivery.

Methods: Surface composition, charge, colloidal stabilities, associations with adenovirus, magneto-tranduction efficiencies, cell internalizations, in vitro toxicities and MRI relaxivities were tested for the particles decorated with varying amounts of PEI.

Results: Moderate PEI-decoration of MNPs results in charge reversal and destabilization.

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