Publications by authors named "D Leongamornlert"
Haematopoietic stem cells maintain blood production throughout life. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies.
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- Haematopoietic stem cells are crucial for lifelong blood production and were studied in young and old mice to understand how these cells change with age.
- Researchers found that mouse stem cells accumulate about 45 somatic mutations per year, which is not drastically different from humans, despite their size and lifespan differences.
- The study revealed that while stem cells independently maintain their populations throughout life, aged mice showed different patterns of clonal diversity and expansion compared to humans, particularly after blood system disturbances.
The epigenetic landscape of cancer is regulated by many factors, but primarily it derives from the underlying genome sequence. Chromothripsis is a catastrophic localized genome shattering event that drives, and often initiates, cancer evolution. We characterized five esophageal adenocarcinoma organoids with chromothripsis using long-read sequencing and transcriptome and epigenome profiling.
View Article and Find Full Text PDFObjectives: The relation of serum androgens and the development of prostate cancer (PCa) is subject of debate. Lower total testosterone (TT) levels have been associated with increased PCa detection and worse pathological features after treatment. However, data from the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) and Prostate Cancer Prevention (PCPT) trial groups indicate no association.
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