Publications by authors named "D Lemmon"
When, where, and how often hominin interbreeding happened is largely unknown. We study the potential for Neanderthal-Denisovan admixture using species distribution models that integrate extensive fossil, archaeological, and genetic data with transient coupled general circulation model simulations of global climate and biomes. Our Pleistocene hindcast of past hominins' habitat suitability reveals pronounced climate-driven zonal shifts in the main overlap region of Denisovans and Neanderthals in central Eurasia.
View Article and Find Full Text PDFIt is widely held that the central monoamine neurotransmitters modulate alcohol intake. Few studies, however, directly assess the relationship between baseline and alcohol-induced monoamine turnover, as well as the change from baseline, as predictors of alcohol intake. Using a nonhuman primate model, this study investigates baseline, alcohol-induced and alcohol-induced change in monoamine activity and their relationship with alcohol intake.
View Article and Find Full Text PDFIt has long been believed that climate shifts during the last 2 million years had a pivotal role in the evolution of our genus Homo. However, given the limited number of representative palaeo-climate datasets from regions of anthropological interest, it has remained challenging to quantify this linkage. Here, we use an unprecedented transient Pleistocene coupled general circulation model simulation in combination with an extensive compilation of fossil and archaeological records to study the spatiotemporal habitat suitability for five hominin species over the past 2 million years.
View Article and Find Full Text PDFArticle Synopsis
- Neuronal cell types in the brain form circuits that influence behavior, specifically in the context of orienting and defensive actions in mice.
- By using functional ultrasound imaging and optogenetics, researchers identified how stimulating different neuronal groups in the superior colliculus activates distinct brain regions and triggers various behaviors.
- Interestingly, this study highlights the involvement of the posterior paralaminar nuclei of the thalamus in suppressing habituation and demonstrates that neurons in downstream areas respond more to threatening visual cues, providing new insights into the brain's organizational structure for controlling instinctive behaviors.
Purpose: To compare short- and long-term effects of adjuvant treatment versus observation after surgery on health-related quality of life (HRQL) of prostate cancer patients.
Patients And Methods: The Southwest Oncology Group (SWOG) intergroup trial compared radical prostatectomy (RP) plus observation versus RP plus adjuvant radiation therapy (RT). Two-hundred seventeen of 425 therapeutic trial patients were eligible and registered to the HRQL study.