Publications by authors named "D Lemaire"
Genome-based testing in oncology is a rapidly expanding area of health care that is the basis of the emerging area of precision medicine. The efficient and considered adoption of novel genomic medicine testing is hampered in Canada by the fragmented nature of health care oversight as well as by lack of clear and transparent processes to support rapid evaluation, assessment, and implementation of genomic tests. This article provides an overview of some key barriers and proposes approaches to addressing these challenges as a potential pathway to developing a national approach to genomic medicine in oncology.
View Article and Find Full Text PDFThe dispersion of uranium in the environment can pose a problem for the health of humans and other living organisms. It is therefore important to monitor the bioavailable and hence toxic fraction of uranium in the environment, but no efficient measurement methods exist for this. Our study aims to fill this gap by developing a genetically encoded FRET-based ratiometric uranium biosensor.
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- Plutonium's strong radiotoxicity and role in the nuclear industry make it a key focus for understanding internal contamination risks.
- The study aimed to explore how plutonium (Pu(IV)) interacts with calmodulin, a common protein in cells, by examining its complexation with the EF-hand motif.
- Using visible and X-ray absorption spectroscopies, researchers identified three different plutonium species at physiological pH, including 1:1 complexes with calmodulin and other significant formations.