Publications by authors named "D Legge"
Article Synopsis
- Cancer-related fatigue (CRF) is a prevalent symptom among individuals with primary brain tumors, but previous studies have largely relied on quantitative data, missing the depth of personal experiences.
- The research involved semi-structured interviews with patients, caregivers, and healthcare professionals, uncovering four key themes: the widespread nature of CRF, its significant impacts, the support provided, and self-management practices by patients.
- Findings reveal a profound lack of targeted information and resources for managing CRF in brain tumor patients, emphasizing the urgent need for specialized support and interventions.
Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthetic demands associated with disease progression. As such, targeting cancer cell metabolism is a promising therapeutic avenue in CRC.
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- About 50% of neuroblastomas with poor prognosis are linked to the over-expression of the MYCN protein, and previous research has shown that targeting PRMT5 leads to cell death in these cases.
- The study evaluates GSK3203591, a new PRMT5 inhibitor, showing that it inhibits MYCN-dependent growth and triggers changes in gene expression and mRNA splicing in MNA neuroblastoma cells, particularly affecting glutamine metabolism.
- In tests on mice, the related compound GSK3326593 demonstrated increased survival, confirming that both drugs exploit PRMT5's role in splicing and regulation of metabolic pathways in MYCN-amplified neuroblastomas.
Background: Carers play an important role in supporting patients diagnosed with high-grade glioma (HGG). However, this experience is frequently distressing and many carers require support.
Objectives: To describe unmet needs of highly distressed carers of people with HGG and recommendations and referrals made by a nurse to support them within the Care-IS trial.
Objective: Intranasal (IN) fentanyl and nitrous oxide (NO) can be combined to provide procedural sedation and analgesia to children. This combination is advantageous because of rapid onset of action and non-parenteral administration, but is associated with increased vomiting. We sought to describe the associations of demographic and procedural factors with early vomiting when using this combination in children.
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