Publications by authors named "D Legendre"

Tracheal stenosis (i.e., the abnormal narrowing of the trachea) can occur due to a variety of inflammatory and infectious processes as well as due to therapeutic procedures undertaken by the patient.

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Cilia are biological structures essential to drive the mobility of secretions and maintain the proper function of the respiratory airways. However, this motile self-cleaning process is significantly compromised in the presence of silicone tracheal prosthesis, leading to biofilm growth and impeding effective treatment. To address this challenge and enhance the performance of these devices, we propose the fabrication of magnetic silicone cilia, with the prospect of their integration onto silicone prostheses.

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Article Synopsis
  • Silicone endotracheal prostheses are good for medical use, but they often develop harmful biofilms that can cause inflammation and complications.
  • The study tested cold atmospheric plasma (CAP) to see if it could inhibit these harmful biofilms, and also assessed its effects on human bronchial cells.
  • Results showed that CAP significantly reduced biofilm viability without being harmful to the bronchial cells, suggesting it could be a useful method to prevent biofilm formation on silicone prostheses.
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The performance of multiphase flow processes is often determined by the distribution of phases inside the equipment. However, controllers in the field are typically implemented based on flow variables, which are simpler to measure, but indirectly connected to performance (e.g.

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Introduction: Single-dose 2-g oral secnidazole (SEC), newly approved by the U.S. Food and Drug administration (FDA) for treatment of trichomoniasis, is a potent 5-nitroimidazole with selective toxicity against various micro-organisms.

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