Publications by authors named "D Leeman"
Background: The 11+Myco MS-PREP® Immunoaffinity Column (IAC) contains a gel suspension of monoclonal antibodies specific to the toxins of interest. Following sample extraction, the IAC is used for cleanup and concentration of mycotoxins prior to analysis by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS).
Objective: This study evaluated the IAC with LC-MS/MS method for Performance Tested Methods SM certification for simultaneous determination and confirmation of Aflatoxins B1, B2, G1, G2, and M1; Deoxynivalenol, Fumonisins B1, B2, and B3; Ochratoxin A; T-2; HT-2; and Zearalenone from corn, wheat, cereal-based baby food (with and without dairy ingredients), paprika, chili powder and animal feed.
Article Synopsis
- Chronic hepatitis B virus (HBV) prevalence and undiagnosed cases in the UK, even with low rates, are hard to measure accurately; this study uses public health data to estimate prevalence among different ethnic groups.
- Out of 714,287 women tested during antenatal care, 0.6% were HBsAg-positive, predominantly from non-White British backgrounds; similarly, 1.9% tested positive in other healthcare settings.
- The study estimates around 268,767 chronic HBV cases in England, with a significant concentration in ethnic minorities, indicating a challenge in meeting WHO targets for HBV elimination as a public health issue.
Ageing impairs the ability of neural stem cells (NSCs) to transition from quiescence to proliferation in the adult mammalian brain. Functional decline of NSCs results in the decreased production of new neurons and defective regeneration following injury during ageing. Several genetic interventions have been found to ameliorate old brain function, but systematic functional testing of genes in old NSCs-and more generally in old cells-has not been done.
View Article and Find Full Text PDFBackground: An increase in acute severe hepatitis of unknown aetiology in previously healthy children in the UK in March, 2022, triggered global case-finding. We aimed to describe UK epidemiological investigations of cases and their possible causes.
Methods: We actively surveilled unexplained paediatric acute hepatitis (transaminase >500 international units per litre) in children younger than 16 years presenting since Jan 1, 2022, through notifications from paediatricians, microbiologists, and paediatric liver units; we collected demographic, clinical, and exposure information.