Publications by authors named "D Ledesma"
Article Synopsis
- Fossil identification is crucial for understanding the impact of environmental changes on ancient species and communities.
- The study uses an apomorphic identification framework to analyze lizard remains from Hall's Cave in Central Texas, revealing at least 11 lizard taxa, including five not previously known from the site.
- This research aims to standardize fossil lizard identification across North America, aiding future discoveries and enhancing our understanding of ancient ecosystems.
Article Synopsis
- Acral lentiginous melanoma (ALM) is a rare but aggressive form of skin cancer that mainly affects palms, soles, and nails, with higher occurrences in dark-skinned populations.
- A study assessed the expression of key proteins linked to tumor growth and treatment resistance (BCL2, MCL1, BIM, and BRAF V600E) in melanoma samples from White and Hispanic patients, noting no significant differences in protein expression between ALM and non-ALM tumors.
- The results suggest that since both ALM and non-ALM tumors frequently express these proteins, patients might benefit from new therapies aimed at inducing apoptosis (programmed cell death).
Article Synopsis
- Granulomatous Mycosis Fungoides (GMF) is a rare and severe type of mycosis fungoides that features a granulomatous infiltrate and generally has worse outcomes than typical mycosis fungoides.
- The study investigated immune responses in GMF and Mycosis Fungoides with Large Cell Transformation (MFLCT) by examining various markers in skin biopsies from 49 patients.
- Findings indicated that patients with GMF showed distinct immune profiles, including increased Tbet, RORγT, and PD-L1, while certain factors like low levels of RORγT and advanced disease stage correlated with poorer survival rates.
We aimed to determine Japanese metastatic castration resistant prostate cancer (CRPC) patients' Ra-223 treatment experience. Patients answered the Cancer Therapy Satisfaction Questionnaire (CTSQ domains: Satisfaction with Therapy [SWT], Expectations of Therapy [ET], Feelings about Side Effects [FSE]), the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) and the FACT-Bone Pain (FACT-BP) Questionnaire at baseline, during (vists 3 and 5) and after treatment (end of observation; EOO). Data from 72 patients were included.
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- Enfortumab vedotin (EV) is a targeted therapy for urothelial carcinoma, and this study evaluates its effectiveness for treating certain skin tumors by assessing Nectin-4 expression.
- Researchers analyzed various skin adnexal carcinomas and benign tumors through immunohistochemical staining, finding that malignant tumors had significantly higher Nectin-4 expression than benign ones.
- The study concludes that since many cutaneous adnexal carcinomas, particularly sebaceous carcinomas, exhibit high Nectin-4 levels, EV could be a viable treatment option for these cancers.