Publications by authors named "D Le Pennec"
Nipah virus (NiV) is a lethal zoonotic paramyxovirus that can be transmitted from person to person through the respiratory route. There are currently no licensed vaccines or therapeutics. A lipopeptide-based fusion inhibitor was developed and previously evaluated for efficacy against the NiV-Malaysia strain.
View Article and Find Full Text PDFArticle Synopsis
- Anatomical 3D-printed nasal casts are important for studying how drugs are delivered inside the nose and provide unique preclinical data not available from animal studies.
- The study analyzed CT scans from 98 patients, revealing anatomical differences in the nasal cavity and identifying three distinct nasal geometry groups, leading to the creation of representative 3D models.
- The research demonstrated that these anatomical variations significantly impact how well different medical devices deliver drugs, especially with nasal sprays and nebulizers, highlighting the need for diverse models to assess drug effectiveness in different populations.
Article Synopsis
- A study was done to see how well different setups deliver inhaled medicine to patients on ventilators after brain surgery.
- The researchers used a special machine to deliver the medicine in four different ways and found that one setup helped deliver much more of the medicine to the lungs.
- They discovered that the best method increased the amount of medicine reaching the lungs by two to three times compared to the other methods, and they think more testing is needed to make sure this method is the best one to use.
Non-Human Primates (NHPs) are particularly relevant for preclinical studies during the development of inhaled biologics. However, aerosol inhalation in NHPs is difficult to evaluate due to a low lung deposition fraction and high variability. The objective of this study was to evaluate the influence of mesh nebulizer parameters to improve lung deposition in macaques.
View Article and Find Full Text PDFNanofitins are small and hyperthermostable alternative protein scaffolds that display physicochemical properties making them suitable for the development of topical therapeutics, notably for the treatment of pulmonary infectious diseases. Local administration of biologics to the lungs involves a particularly stressful step of nebulization that is poorly tolerated by most antibodies, which limits their application by this delivery route. During the COVID-19 pandemic, we generated anti-SARS-CoV-2 monomeric Nanofitins of high specificity for the spike protein.
View Article and Find Full Text PDF