Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the French experience.

Background: Pregnancy in women with paroxysmal nocturnal hemoglobinuria is rare, with few reports on maternal and fetal mortality rates.

Design And Methods: A specific questionnaire designed to solicit data on pregnancies in women with paroxysmal nocturnal hemoglobinuria was sent to all members of the French Society of Hematology in January 2008.

Results: We identified 27 pregnancies in 22 women at 10 French Society of Hematology centers between 1978 and 2008.