Publications by authors named "D Langhoff"
Background: Spatial biology is an emerging concept to interrogate tumor heterogeneity. The NanoString GeoMx® Digital Spatial Profiling (DSP) platform has become increasingly available. It combines high-plex analysis of protein or messenger RNA expression using barcoded antibodies or oligonucleotide probes with investigator-driven selection of regions of interest.
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- Prostate cancer has different types of cancer cells that can act in various ways, and scientists are trying to understand how these cells are located within a tumor.
- Researchers used a special technique to look at 47 proteins in different parts of tumors from five patients to see how they behave.
- They found that a protein called BAD was more active in the center of tumors and this high activity might help the cancer grow faster; patients with high BAD levels had a shorter time before their cancer came back.
We have utilized a gene from bacteriophage T3 that encodes the enzyme S-adenosylmethionine hydrolase (SAMase) to generate transgenic tomato plants that produce fruit with a reduced capacity to synthesize ethylene. S-adenosylmethionine (SAM) is the metabolic precursor of 1-aminocyclopropane-1-carboxylic acid, the proximal precursor to ethylene. SAMase catalyzes the conversion of SAM to methylthioadenosine and homoserine.
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