Publications by authors named "D Landau"
Background: X-linked hypophosphatemic rickets (XLH) is associated with uninhibited FGF23 activity, which leads to phosphaturia, hypophosphatemia and depressed active vitamin D (1,25OH2D) levels. Conventional treatment with phosphate supplements and vitamin D analogs may lead to hypercalciuria (HC), nephrocalcinosis (NC) and hyperparathyroidism. We investigated the effects of burosumab treatment, an anti-FGF23 monoclonal antibody recently approved for XLH, on these complications.
View Article and Find Full Text PDFBackground: C3 Glomerulopathy (C3G) is a complement-mediated disease, with predominant C3 deposits, where pathogenic genetic variants in complement system components and circulating autoantibodies result in loss of control of the alternative pathway, have been described. A high incidence of disease recurrence including graft failure has been reported after kidney transplantation (KTx). Currently treatment modalities for preventing and treating post KTx C3G recurrence (plasma exchange, rituximab and eculizumab) in adults have yielded inconsistent results.
View Article and Find Full Text PDFArticle Synopsis
- * The study reveals that RAS mutations transform specific blood cell progenitors (granulocyte-monocyte progenitors) that have already acquired other mutations, suggesting advanced leukemia can arise from different cell types than initial clones.
- * RAS-mutant leukemia stem cells show resistance to the treatment drug venetoclax due to changes in gene expression, leading to worse treatment responses and relapses characterized by monocytic features, highlighting the impact of genetic drivers on therapy effectiveness.
Aim: Paediatricians using instant messaging phone apps for informal medical discussions poses ethical and legal risks. We filled a gap in the research, by assessing the use of apps and the possible risks.
Methods: A national, cross-sectional, questionnaire study was conducted in Israel from 11 August to 20 November 2019.
Article Synopsis
- CRISPRmap is a new method for optical pooled genetic screening that allows researchers to study spatial phenotypes without destroying cells, focusing on how cells respond to CRISPR modifications.
- This method integrates guide-identifying barcodes with advanced imaging techniques like immunofluorescence and RNA detection to improve the efficiency of reading the genetic information.
- In a study using breast cancer cells, CRISPRmap helped identify potentially harmful gene mutations associated with DNA damage repair, providing insights into their impact on treatment responses.